New paper out!

In the latest collaborative publication (De Baere lab, Martínez Morales lab & Tena lab) with StarT fellows Víctor López Soriano (ESR3), Soraya Kalayanamontri (ESR2) and Alfredo Dueñas Rey (ESR7) is shown that through extensive comparative 3D genome mapping, based on genome-wide (Hi-C), promoter-centric (HiChIP) and locus-specific (UMI-4C) assays of human neural retina and RPE, that gene regulation at key loci for inherited retinal disease (IRD) is likely mediated by tissue-specific chromatin interactions. A comparative 3D genome analysis between neural retina and RPE/choroid revealed that almost 60% of 290 known IRD genes were marked by differential 3D genome structure and/or cis-regulatory interactions! One of these genes is ABCA4, which is implicated in the most common autosomal recessive IRD.